WFU

2017年2月27日 星期一

睡眠呼吸中止症簡介(下)

在這次的介紹中, 我們會把重點放在睡眠呼吸中止症的診斷及相關風險方面

那我有沒有阻塞型睡眠呼吸中止症呢?

    有許多症狀都跟阻塞性睡眠呼吸中止症相關例如最常見的兩個症狀就是慢性打呼以及白天嗜睡。但是如果真的要選一個最能預測睡眠呼吸中止症的症狀的話那應該可以用 夜間嗆醒 (Nocturnal choking or gasping) 來做一個初步的評估。根據研究當出現有 夜間嗆醒“ 有很高的機會可以確診阻塞型睡眠呼吸中止症 (sensitivity 52%, specificity 84%)(8)

該如何確診睡眠呼吸中止症呢?

    在睡眠檢查室中,  接受多頻式睡眠檢查(Polysomnography)是診斷睡眠呼吸中止症的黃金標準。檢查方式十分簡單由於我們要檢查的是睡眠時呼吸道的狀態所以檢查是在夜間及凌晨時進行在醫師安排好檢查之後你可以洗好澡吃完晚餐帶著明天早上要上班的換洗衣物直接到睡眠檢查室報到在檢查室裡睡眠檢查技師會將各種檢測的儀器連接至您身上接著只需要放輕鬆一覺到天明就可以了隔天睡醒時就是檢查做完的時候您可以換好衣物後正常上班完全不會影響白天的正常作息。

多頻式睡眠檢查時, 會在睡眠時監測許多指標, 為醫師提供睡眠結構的資訊



睡眠呼吸中止症可能引起什麼問題呢?

日間生活功能失常由於阻塞性睡眠呼吸中止症會造成白天嗜睡,疲累,注意力   不集中所以白天的生活工作甚至認知功能都可能受到影響(3,9-12)

交通意外研究顯示在有阻塞性睡眠呼吸中止症的病人中發生車禍的機會是正常人的2-3(9)。研究也顯示成功治療可以顯著的提升車輛駕駛的專注力並且減少車禍機會。

心血管疾病有阻塞型睡眠呼吸中止症的病患尤其是中重度的患者比一般人更容易得到心血管的疾病其中包括全身性高血壓肺動脈高壓冠狀動脈疾病心律不整心臟衰竭甚至腦中風。

代謝性症候群及第二型糖尿病許多有睡眠呼吸中止症的病患都有體重過重的問題所以當研究顯示這些組群也容易有代謝性症候群及第二型糖尿病時(13,14), 臨床醫師並不感到意外但是也有其他進一步的研究顯示即使排除掉體重因素之後有睡眠呼吸中止症的病人仍然比一般人更容易有代謝性症候群及第二型糖尿病(15-17), 這種情形在重度睡眠呼吸中止症中更為明顯(17)

非酒精性指肪肝研究顯示有阻塞型睡眠呼吸中止症的病人比一般人容易有非酒精性脂肪肝目前推測可能的原因是和低血氧造成的發炎反應相關(18,19)


透過以上的說明希望您能對睡眠呼吸中止症有所了解其實要診斷睡眠呼吸中止症不是件困難的事如果真的有睡眠方面的困擾請找個時間到醫院找醫師討論看看喔 ! 
參考資料:
1. Epstein LJ, Kristo D, Strollo PJ Jr, et al. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med 2009; 5:263.
2. Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA 2004; 291:2013.
3. Young T, Palta M, Dempsey J, et al. Burden of sleep apnea: rationale, design, and major findings of the Wisconsin Sleep Cohort study. WMJ 2009; 108:246.
4. Jennum P, Riha RL. Epidemiology of sleep apnoea/hypopnoea syndrome and sleep-disordered breathing. Eur Respir J 2009; 33:907.
5. Tufik S, Santos-Silva R, Taddei JA, Bittencourt LR. Obstructive sleep apnea syndrome in the Sao Paulo Epidemiologic Sleep Study. Sleep Med 2010; 11:441.
6. Quintana-Gallego E, Carmona-Bernal C, Capote F, et al. Gender differences in obstructive sleep apnea syndrome: a clinical study of 1166 patients. Respir Med 2004; 98:984.
7. Peppard PE, Young T, Palta M, et al. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA 2000; 284:3015.
8. Myers KA, Mrkobrada M, Simel DL. Does this patient have obstructive sleep apnea?: The Rational Clinical Examination systematic review. JAMA 2013; 310:731.
9. George CF. Sleep apnea, alertness, and motor vehicle crashes. Am J Respir Crit Care Med 2007; 176:954.
10. Yaffe K, Laffan AM, Harrison SL, et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA 2011; 306:613.
11. Strohl K, Bonnie R, Findley L, et al. Sleep apnea, sleepiness and driving risk. American Journal of Respiratory and Critical Care Medicine 1999; 150:1463.
12. Olaithe M, Bucks RS. Executive dysfunction in OSA before and after treatment: a meta-analysis. Sleep 2013; 36:1297.
13. Marshall NS, Wong KK, Phillips CL, et al. Is sleep apnea an independent risk factor for prevalent and incident diabetes in the Busselton Health Study? J Clin Sleep Med 2009; 5:15.
14. Reichmuth KJ, Austin D, Skatrud JB, Young T. Association of sleep apnea and type II diabetes: a population-based study. Am J Respir Crit Care Med 2005; 172:1590.
15. Botros N, Concato J, Mohsenin V, et al. Obstructive sleep apnea as a risk factor for type 2 diabetes. Am J Med 2009; 122:1122.
16. Celen YT, Hedner J, Carlson J, Peker Y. Impact of gender on incident diabetes mellitus in obstructive sleep apnea: a 16-year follow-up. J Clin Sleep Med 2010; 6:244.
17. Kendzerska T, Gershon AS, Hawker G, et al. Obstructive sleep apnea and incident diabetes. A historical cohort study. Am J Respir Crit Care Med 2014; 190:218.
18. Musso G, Cassader M, Olivetti C, et al. Association of obstructive sleep apnoea with the presence and severity of non-alcoholic fatty liver disease. A systematic review and meta-analysis. Obes Rev 2013; 14:417.
19. Glünder G, Wieliczko A. [The pathogenicity of Campylobacter jejuni as a monoinfection and as a mixed infection with Escherichia coli 078:K80 in broilers]. Berl Munch Tierarztl Wochenschr 1990; 103:302.

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